How are cannabis edibles metabolized differently than smoked cannabis?

Cannabis edibles are metabolized differently than smoked cannabis primarily due to the way they are processed in the body. When cannabis is consumed in edible form, it is first digested and then absorbed into the bloodstream through the gastrointestinal tract. This process leads the cannabinoids to be sent to the liver, where they undergo a transformation into 11-hydroxy-THC, a potent metabolite. This metabolic pathway results in a delayed onset of effects, typically taking 30 minutes to 2 hours to feel the impact compared to the almost immediate effects of smoked cannabis. Additionally, because 11-hydroxy-THC is considered more potent than THC itself, this can lead to stronger and potentially longer-lasting effects.

This difference in metabolism is significant for users to understand, as it influences not only the timing and intensity of the experience but also dosing considerations for those consuming cannabis for therapeutic or recreational purposes.

The other choices do not accurately represent the pharmacokinetics of cannabis. For instance, edibles taking longer to act (rather than quicker), and smoked cannabis does not generate longer-lasting effects than edibles in all cases, as edibles can maintain effects for several hours due to their prolonged metabolism. Lastly, the statement about only edibles