Which group of compounds is responsible for the interaction with the endocannabinoid system?

Cannabinoids are the specific group of compounds known for their interaction with the endocannabinoid system (ECS) in the human body. This system is a complex signaling network involved in various physiological processes such as mood regulation, pain sensation, appetite, and immune response. Cannabinoids, including well-known compounds like THC (tetrahydrocannabinol) and CBD (cannabidiol), mimic the effects of naturally occurring endocannabinoids in the body, binding to cannabinoid receptors (CB1 and CB2) to influence these biological functions.

While terpenes and flavonoids are also found in cannabis and contribute to the plant's overall effects and therapeutic potential, their primary roles are not to directly interact with the ECS. Terpenes may enhance or modify the effects of cannabinoids, and flavonoids contribute to the plant's color and flavor profile, as well as providing their own potential health benefits. Chlorophylls are primarily involved in photosynthesis and do not play a role in interactions with the ECS. Thus, cannabinoids stand out as the key compounds that actively engage with the endocannabinoid system.